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8 ± 4. De Benedetti b a Institut de Pharmacologie et Toxicologie, Universit~ de Lausanne, 27, Rue du Bugnon, Facult~ de Mddecine, 1005 Lausanne, Switzerland b Dipartimento di Chimica, Universith di Modena e Reggio Emilia, 41100 Modena, Italy c Pharmaceutical RD Division, Recordati, 20148 Milan, Italy Abstract In this chapter we summarize some aspects of the structure-functional relationship of the o~1a and otlb-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor.
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