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Strategies. MARKEY Introduction 143 Phase I Biotransformations 146 Liver Microsomal Cytochrome P450 Monooxygenases 146 CYP-Mediated Chemical Transformations 149 Non-CYP Biotransformations 152 Phase II Biotransformations (Conjugations) 156 Glucuronidation 156 Sulfation 157 Acetylation 158 Additional Effects on Drug Metabolism 159 Enzyme Induction and Inhibition 159 Species 159 Sex 160 Age 160 CHAPTER 12 RAYMOND MILLER Introduction 129 Analysis of Pharmacokinetic Data 129 Structure of Pharmacokinetic Models Fitting Individual Data 130 Population Pharmacokinetics 130 Population Analysis Methods 131 Model Applications 134 129 Methods of Analysis of Drugs and Drug Metabolites SANFORD P.

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